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MIF was revealed to rescue neurons from oxidative anxiety induced apoptosis by inhibiting caspase-3 activation, and MIF-knockout mice also had more useless neurons, in addition to a larger infarct dimension immediately after induction of an experimental stroke [124]. according to these findings, improving the CD74 pathway might signify a singular

Besides MIFs immunogenic part, it's got also been described to play a very important function in the course of neural embryonic enhancement. Shen et al. (2013) shown that the MIF pathway is required to the survival of statoacoustic ganglia and sensory hair cells in a zebrafish model. utilizing knockdown with antisense oligonucleotide morpholinos (M

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